While the role of life events on residential mobility for the general population is well documented, little is known for low-income, subsidised households. Insights into this line of inquiry are instrumental for improving housing policies and programmes that aim for a more equal distribution of residents across the economic spectrum. The present study draws on a unique data set that covers the entire low-income population participating in the Housing Choice Voucher (HCV) programme from 2007 to 2013 in the state of Florida, USA. Results show that life events are strongly and significantly related to mobility decisions, while the relationship between life events and changes in neighbourhood poverty is less prominent. In light of this, a full understanding of residential mobility requires the consideration of life events by accounting for housing assistance, given its compounding effect on the mobility process and outcomes for low-income households.